Biotin Conjugated Human CD200R1 Recombinant Rabbit Monoclonal Antibody [PSH05-28] (HA722598B)

UNIPROT #

Q8TD46

PROTEIN NAME

Human CD200R1

SYNONYMS

CD 200R antibody;CD200 cell surface glycoprotein receptor antibody;CD200 receptor 1 antibody;Cd200r1 antibody;Cell surface glycoprotein CD200 receptor 1 antibody;Cell surface glycoprotein OX2 receptor 1 antibody;Cell surface glycoprotein OX2 receptor antibody;cell surface glycoprotein receptor CD200 antibody;CRTR 2 antibody;CRTR2 antibody;HCRTR2 antibody;MO2R1_HUMAN antibody;MOX2 receptor antibody;MOX2R antibody;OX2R antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cell surface transmembrane glycoprotein CD200 receptor 1 is a protein that in humans is encoded by the CD200R1 gene. CD200R1 is expressed on the surface of myeloid cells and CD4+ T cells. It interacts with CD200 transmembrane glycoprotein that can be expressed on variety of cells including neurons, epithelial cells, endothelial cells, fibroblasts, and lymphoid cells. CD200R1 activation regulates the expression of pro-inflammatory molecules such as tumor necrosis factor (TNF-alpha), interferons, and inducible nitric oxide synthase (iNOS). This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants.