beta COP Rabbit Polyclonal Antibody (HA500588)

UNIPROT #

P53618

PROTEIN NAME

beta COP

SYNONYMS

Beta-coat protein antibody;Beta-COP antibody;betacop antibody;Coatomer beta subunit antibody;Coatomer protein complex subunit beta 1 antibody;Coatomer protein complex subunit beta antibody;Coatomer subunit beta antibody;COPB antibody;COPB_HUMAN antibody;Copb1 antibody;DKFZp761K102 antibody;FLJ10341 antibody

SUBCELLULAR LOCATION

Cytoplasm, Golgi apparatus membrane, Cytoplasmic vesicle, COPI-coated vesicle membrane, Cell membrane, Endoplasmic reticulum-Golgi intermediate compartment.

FUNCTION

The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. Plays a functional role in facilitating the transport of kappa-type opioid receptor mRNAs into axons and enhances translation of these proteins. Required for limiting lipid storage in lipid droplets. Involved in lipid homeostasis by regulating the presence of perilipin family members PLIN2 and PLIN3 at the lipid droplet surface and promoting the association of adipocyte surface triglyceride lipase (PNPLA2) with the lipid droplet to mediate lipolysis (By similarity).