beta Amyloid 1-42 Recombinant Rabbit Monoclonal Antibody (IRS247RB)

UNIPROT #

P12023

PROTEIN NAME

beta Amyloid 1-42

SYNONYMS

A4 antibody;A4_HUMAN antibody;AAA antibody;ABETA antibody;ABPP antibody;AICD-50 antibody;AICD-57 antibody;AICD-59 antibody;AID(50) antibody;AID(57) antibody;AID(59) antibody;Alzheimer disease amyloid protein antibody;Amyloid intracellular domain 50 antibody;Amyloid intracellular domain 57 antibody;Amyloid intracellular domain 59 antibody;APP antibody;APPI antibody;Beta amyloid protein 42 antibody;Beta APP42 antibody;Beta-APP40 antibody;Beta-APP42 antibody;C31 antibody;Cerebral vascular amyloid peptide antibody;CVAP antibody;Gamma-CTF(50) antibody;Gamma-CTF(57) antibody;Gamma-CTF(59) antibody;PN-II antibody;PreA4 antibody;Protease nexin-II antibody;S-APP-alpha antibody;S-APP-beta antibody

SUBCELLULAR LOCATION

Cell membrane, Membrane, Perikaryon, Cell projection, growth cone, Membrane, clathrin-coated pit, Early endosome, Cytoplasmic vesicle.

FUNCTION

Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of neurons. It functions as a cell surface receptor and has been implicated as a regulator of synapse formation, neural plasticity, antimicrobial activity, and iron export. It is coded for by the gene APP and regulated by substrate presentation. APP is best known as the precursor molecule whose proteolysis generates amyloid beta (Aβ), a polypeptide containing 37 to 49 amino acid residues, whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients.