BCMA Recombinant Rabbit Monoclonal Antibody [PSH17-94] (HA723959)

UNIPROT #

Q02223

PROTEIN NAME

BCMA

SYNONYMS

B cell maturation antigen antibody;B cell maturation factor antibody;B cell maturation protein antibody;B-cell maturation protein antibody;BCM antibody;BCMA antibody;CD269 antibody;CD269 antigen antibody;TNFRSF17 antibody;TNR17_HUMAN antibody;Tumor necrosis factor receptor superfamily member 17 antibody

SUBCELLULAR LOCATION

Cell membrane, Endomembrane system.

FUNCTION

B-cell maturation antigen (BCMA or BCM), also known as tumor necrosis factor receptor superfamily member 17 (TNFRSF17), is a protein that in humans is encoded by the TNFRSF17 gene. TNFRSF17 is a cell surface receptor of the TNF receptor superfamily which recognizes B-cell activating factor (BAFF). Serum B-cell maturation antigen (sBCMA) is the cleaved form of BCMA, found at low levels in the serum of normal patients and generally elevated in patients with multiple myeloma (MM). The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is preferentially expressed in mature B lymphocytes, and may be important for B cell development and autoimmune response. This receptor has been shown to specifically bind to the tumor necrosis factor (ligand) superfamily, member 13b (TNFSF13B/TALL-1/BAFF), and to lead to NF-kappaB and MAPK8/JNK activation. This receptor also binds to various TRAF family members, and thus may transduce signals for cell survival and proliferation.