BCL6 Recombinant Mouse Monoclonal Antibody (IRS097MS)

UNIPROT #

P41182

PROTEIN NAME

BCL6

SYNONYMS

B cell CLL/lymphoma 6 antibody;B cell lymphoma 6 protein antibody;B-cell lymphoma 5 protein antibody;B-cell lymphoma 6 protein antibody;BCL 5 antibody;Bcl 6 antibody;BCL-5 antibody;BCL-6 antibody;BCL5 antibody;BCL6 antibody;BCL6_HUMAN antibody;BCL6A antibody;cys his2 zinc finger transcription factor antibody;cys-his2 zinc finger transcription factor antibody;LAZ 3 antibody;LAZ 3 protein antibody;LAZ3 antibody;Lymphoma Associated Zinc Finger Gene On Chromosome 3 (LAZ3) antibody;Lymphoma associated zinc finger gene on chromosome 3 antibody;Protein LAZ-3 antibody;ZBTB 27 antibody;ZBTB27 antibody;Zinc finger and BTB domain containing protein 27 antibody;Zinc finger and BTB domain-containing protein 27 (ZBTB27) antibody;Zinc finger and BTB domain-containing protein 27 antibody;Zinc Finger Protein 51 (ZNF51) antibody;Zinc finger protein 51 antibody;zinc finger transcription factor BCL6S antibody;ZNF 51 antibody;ZNF51 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

The Bcl-6 protein (B-cell CLL/lymphoma 6, zinc finger protein 51) is a nuclear zinc finger transcription factor with an N-terminal POZ domain. Bcl-6 represses p53 transcription by binding 2 specific DNA sites within the p53 promoter region and accordingly, p53 expression is absent in germinal centre B-cells where Bcl-6 is highly expressed. Most notably, constitutive expression of Bcl-6 protects B-cell lines from apoptosis induced by DNA damage. Bcl-6 is mainly used in the classification of B-cell lymphomas. In malignant lymphomas, Bcl-6 protein is most commonly detected in germinal centre neoplasms including follicular lymphoma, Burkitt lymphoma, diffuse large B-cell lymphoma (40%), lymphocyte predominant Hodgkin lymphoma, and even in peripheral T-cell lymphoma with follicular localization (“follicular T cell lymphoma”). It is also found in CD30+ anaplastic large cell lymphoma. Bcl-6 expression is virtually absent in acute lymphatic leukaemia and mantle cell lymphoma. Normal tonsil is recommended as positive and negative tissue control. Virtually all the germinal centre B-cells must show a moderate to strong nuclear staining reaction, while an at least weak to moderate nuclear staining reaction must be seen in the majority of squamous epithelial cells. In the mantle zones and interfollicular areas only dispersed cells should display a positive nuclear staining reaction.