BCL2L12 Recombinant Rabbit Monoclonal Antibody [JE51-66] (ET7110-02)

UNIPROT #

Q9HB09

PROTEIN NAME

BCL2L12

SYNONYMS

B2L12_HUMAN antibody;BCL 2 like 12 (proline rich) antibody;BCL 2 like 12 antibody;BCL 2 like 12 isoform 1 antibody;Bcl 2 like 12 protein antibody;Bcl 2 related proline rich protein antibody;Bcl-2-like protein 12 antibody;Bcl-2-related proline-rich protein antibody;BCL2 like 12 (proline rich) antibody;BCL2 like 12 antibody;BCL2 like 12 isoform 1 antibody;Bcl2 like 12 protein antibody;Bcl2 related proline rich protein antibody;Bcl2-L-12 antibody;BCL2L12 antibody;BPR antibody;MGC120313 antibody;MGC120314 antibody;MGC120315 antibody

SEQUENCE SIMILARITIES

Belongs to the Bcl-2 family.

TISSUE SPECIFICITY

Expressed mainly in breast, thymus, prostate, fetal liver, colon, placenta, pancreas, small intestine, spinal cord, kidney, and bone marrow and to a lesser extent in many other tissues. Isoform 2 is primarily expressed in skeletal muscle.

SUBCELLULAR LOCATION

Nucleus, membrane.

FUNCTION

Bcl-2-like protein 12 is a protein that in humans is encoded by the BCL2L12 gene. The protein encoded by this gene belongs to the Bcl-2 protein family. Bcl-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a Bcl-2 homology domain 2 (BH2). The function of this gene has not yet been determined. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. Bcl2L12 expression is upregulated in most human glioblastomas. Expression of Bcl2L12 results in resistance to apoptosis. Bcl2L12 directly neutralizes caspase-7 (CASP7) and indirectly neutralizes caspase-3 (CASP3) by an indirect mechanism.[7] Both caspase enzymes are known to play essential roles in the execution phase of apoptosis.