ATF6 Recombinant Mouse Monoclonal Antibody - BSA and Azide free [8D3-R] (HA610193)

UNIPROT #

P18850

PROTEIN NAME

ATF6

SYNONYMS

Activating transcription factor 6 alpha antibody;Activating transcription factor 6 antibody;ATF 6 antibody;ATF6 alpha antibody;ATF6 antibody;ATF6-alpha antibody;ATF6A antibody;ATF6A_HUMAN antibody;cAMP dependent transcription factor ATF 6 alpha antibody;cAMP-dependent transcription factor ATF-6 alpha antibody;Cyclic AMP dependent transcription factor ATF 6 alpha antibody;DKFZp686P2194 antibody;ESTM49 antibody;FLJ21663 antibody;Processed cyclic AMP dependent transcription factor ATF 6 alpha antibody;Processed cyclic AMP-dependent transcription factor ATF-6 alpha antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum. Nucleus.

FUNCTION

Transmembrane glycoprotein of the endoplasmic reticulum that functions as a transcription activator and initiates the unfolded protein response (UPR) during endoplasmic reticulum stress. Cleaved upon ER stress, the N-terminal processed cyclic AMP-dependent transcription factor ATF-6 alpha translocates to the nucleus where it activates transcription of genes involved in the UPR. Binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N9-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. Could also be involved in activation of transcription by the serum response factor. May play a role in foveal development and cone function in the retina.