Aquaporin 2 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH09-19] (HA751273)

UNIPROT #

P41181

PROTEIN NAME

Aquaporin 2

SYNONYMS

ADH water channel antibody;AQP 2 antibody;AQP CD antibody;AQP-2 antibody;AQP-CD antibody;AQP2 antibody;AQP2_HUMAN antibody;AQPCD antibody;Aquaporin 2 collecting duct antibody;Aquaporin CD antibody;Aquaporin-2 antibody;Aquaporin-CD antibody;Aquaporin2 antibody;Aquaporine 2 antibody;Collecting duct water channel protein antibody;MGC34501 antibody;Water channel aquaporin 2 antibody;Water channel protein for renal collecting duct antibody;WCH CD antibody;WCH-CD antibody;WCHCD antibody

SUBCELLULAR LOCATION

Apical cell membrane, Basolateral cell membrane, Cell membrane, Cytoplasmic vesicle membrane, Golgi apparatus, trans-Golgi network membrane

FUNCTION

Aquaporin-2 (AQP-2) is found in the apical cell membranes of the kidney's collecting duct principal cells and in intracellular vesicles located throughout the cell. It is encoded by the AQP2 gene.It is the only aquaporin regulated by vasopressin.The basic job of aquaporin 2 is to reabsorb water from the urine while its being removed from the blood by the kidney. Aquaporin 2 is in kidney epithelial cells and usually lies dormant in intracellular vesicle membranes. When it is needed, vasopressin binds to the cell surface vasopressin receptor thereby activating a signaling pathway that causes the aquaporin 2 containing vesicles to fuse with the plasma membrane, so the aquaporin 2 can be used by the cell.