Apolipoprotein CIII Recombinant Rabbit Monoclonal Antibody [PSH24-47] (HA724449)

UNIPROT #

P02656

PROTEIN NAME

Apolipoprotein CIII

SYNONYMS

APOC3 antibody;APO C3 antibody;Apo CIII antibody;Apo-CIII antibody;APOC 3 antibody;ApoC III antibody;ApoC-III antibody;APOC3 antibody;APOC3_HUMAN antibody;ApoCIII antibody;Apolipoprotein C III antibody;Apolipoprotein C-III antibody;Apolipoprotein C3 antibody;ApolipoproteinCIII antibody;MGC150353 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Apolipoprotein C-III also known as apo-CIII, and apolipoprotein C3, is a protein that in humans is encoded by the APOC3 gene. Apo-CIII is secreted by the liver as well as the small intestine, and is found on triglyceride-rich lipoproteins such as chylomicrons, very low density lipoprotein (VLDL), and remnant cholesterol. APOC3 inhibits lipoprotein lipase and hepatic lipase; it is thought to inhibit hepatic uptake of triglyceride-rich particles. The APOA1, APOC3 and APOA4 genes are closely linked in both rat and human genomes. The A-I and A-IV genes are transcribed from the same strand, while the A-1 and C-III genes are convergently transcribed. An increase in apoC-III levels induces the development of hypertriglyceridemia. Recent evidence suggests an intracellular role for Apo-CIII in promoting the assembly and secretion of triglyceride-rich VLDL particles from hepatic cells under lipid-rich conditions. However, two naturally occurring point mutations in human apoC3 coding sequence, namely Ala23Thr and Lys58Glu have been shown to abolish the intracellular assembly and secretion of triglyceride-rich VLDL particles from hepatic cells.