AMID Recombinant Rabbit Monoclonal Antibody [PSH15-60] (HA723767)

UNIPROT #

Q9BRQ8

PROTEIN NAME

AMID

SYNONYMS

5430437E11Rik antibody;aifm2 antibody;AIFM2_HUMAN antibody;AMID antibody;Apoptosis inducing factor (AIF) homologous mitochondrion associated inducer of death antibody;Apoptosis inducing factor (AIF) like mitochondrion associated inducer of death antibody;Apoptosis inducing factor mitochondrion associated 2 antibody;Apoptosis-inducing factor 2 antibody;Apoptosis-inducing factor homologous mitochondrion-associated inducer of death antibody;Apoptosis-inducing factor-like mitochondrion-associated inducer of death antibody;Cys51Stop antibody;Ferroptosis suppressor protein 1 antibody;FSP1 antibody;HGNC11998 antibody;p53 responsive gene 3 antibody;p53 tumor suppressor antibody;p53-responsive gene 3 protein antibody;PRG3 antibody;TRP53 antibody;Tumor protein p53 antibody

SUBCELLULAR LOCATION

Lipid droplet, Cell membrane, Cytoplasm, Mitochondrion membrane, Nucleus.

FUNCTION

Apoptosis-inducing factor 2 (AIFM2), also known as ferroptosis suppressor protein 1 (FSP1), apoptosis-inducing factor-homologous mitochondrion-associated inducer of death (AMID), is a protein that in humans is encoded by the AIFM2 gene, also known as p53-responsive gene 3 (PRG3), on chromosome 10. The AIFM2 gene encodes the FSP1 protein encoded by this gene has significant homology to NADH oxidoreductases and the apoptosis-inducing factor PDCD8/AIF. Although it was originally proposed that this protein induce apoptosis due to its similarity with AIF, findings from James Olzmann's group at UC Berkeley and Marcus Conrad's group at the Helmholtz Institute demonstrated that the primary cellular function of FSP1 is to suppress lipid peroxidation and the induction of the regulated, non-apoptotic cell death pathway known as ferroptosis. Mechanistically, FSP1 reduces oxidized coenzyme Q10 (i.e., ubiquinone) to its reduced form (i.e., ubiquinol), which functions as an excellent lipophilic antioxidant to prevent the propagation of lipid peroxidation. FSP1 also may act through the reduction of other molecules, such as vitamin E and vitamin K.