Alpha 1 antitrypsin Recombinant Rabbit Monoclonal Antibody [PSH16-21] (HA723819)

UNIPROT #

P07758

PROTEIN NAME

Alpha 1 antitrypsin

SYNONYMS

A1A antibody;A1AT antibody;A1AT_HUMAN antibody;AAT antibody;Alpha 1 antiproteinase antibody;Alpha 1 antitrypsin antibody;Alpha 1 antitrypsin null antibody;Alpha 1 protease inhibitor antibody;Alpha-1 protease inhibitor antibody;Alpha-1-antiproteinase antibody;alpha1 proteinase inhibitor antibody;Alpha1AT antibody;Dom1 antibody;PI antibody;PI1 antibody;PRO0684 antibody;PRO2275 antibody;Serine (or cysteine) proteinase inhibitor clade A member 1 antibody;Serine protease inhibitor 1-1 antibody;Serine protease inhibitor A1a antibody;Serpin A1 antibody;Serpin A1a antibody;Serpin peptidase inhibitor clade A member 1 antibody;Serpina1 antibody;Short peptide from AAT antibody;SPAAT antibody;Spi1-1 antibody

SUBCELLULAR LOCATION

Secreted.

FUNCTION

Inhibitor of serine proteases. Its primary target is elastase, but it also has a moderate affinity for plasmin and thrombin. Irreversibly inhibits trypsin, chymotrypsin and plasminogen activator. The aberrant form inhibits insulin-induced NO synthesis in platelets, decreases coagulation time and has proteolytic activity against insulin and plasmin. Reversible chymotrypsin inhibitor. It also inhibits elastase, but not trypsin. Its major physiological function is the protection of the lower respiratory tract against proteolytic destruction by human leukocyte elastase (HLE). A disorder whose most common manifestation is emphysema, which becomes evident by the third to fourth decade. A less common manifestation of the deficiency is liver disease, which occurs in children and adults, and may result in cirrhosis and liver failure. Environmental factors, particularly cigarette smoking, greatly increase the risk of emphysema at an earlier age.