ALK Recombinant Rabbit Monoclonal Antibody [PSH24-98] (HA724493)

UNIPROT #

Q9UM73

PROTEIN NAME

ALK

SYNONYMS

Alk antibody;ALK tyrosine kinase receptor antibody;ALK/EML4 fusion gene, included antibody;ALK/NPM1 fusion gene, included antibody;ALK_HUMAN antibody;anaplastic lymphoma kinase (Ki-1) antibody;Anaplastic lymphoma kinase antibody;Anaplastic lymphoma kinase Ki1 antibody;anaplastic lymphoma receptor tyrosine kinase antibody;CD 246 antibody;CD246 antibody;CD246 antigen antibody;EC 2.7.10.1 antibody;Ki 1 antibody;Ki1 antibody;mutant anaplastic lymphoma kinase antibody;NBLST 3 antibody;NBLST3 antibody;Tcrz antibody;TFG/ALK antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Anaplastic lymphoma kinase (ALK) also known as ALK tyrosine kinase receptor or CD246 (cluster of differentiation 246) is an enzyme that in humans is encoded by the ALK gene. The receptor ALK plays a pivotal role in cellular communication and in the normal development and function of the nervous system. This observation is based on the extensive expression of ALK messenger RNA (mRNA) throughout the nervous system during mouse embryogenesis. In vitro functional studies have demonstrated that ALK activation promotes neuronal differentiation of PC12 or neuroblastoma cell lines. ALK is critical for embryonic development in Drosophila. Flies lacking the receptor die due to failure of founder cell specification in embryonic visceral muscle. However, while ALK knockout mice exhibit defects in neurogenesis and testosterone production, they remain viable, suggesting that ALK is not critical to their developmental processes. ALK regulates retinal axon targeting, growth and size, synapse development at the neuromuscular junction, behavioral responses to ethanol, and sleep. It restricts and constrains learning and long-term memory and small-molecule inhibitors of the ALK receptor can improve learning, long-term memory, and extend healthy lifespan. ALK is also a candidate thinness gene, as its genetic deletion leads to resistance to diet- and leptin-mutation-induced obesity.