ALIX Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [JM85-31] (HA750439)

UNIPROT #

Q8WUM4

PROTEIN NAME

ALIX

SYNONYMS

AIP1 antibody;ALG 2 interacting protein 1 antibody;ALG-2-interacting protein 1 antibody;ALG2 interacting protein X antibody;Alix antibody;Apoptosis linked gene 2 interacting protein X antibody;Dopamine receptor interacting protein 4 antibody;DRIP4 antibody;Hp95 antibody;KIAA1375 antibody;MGC17003 antibody;PDC6I_HUMAN antibody;PDCD6 interacting protein antibody;PDCD6-interacting protein antibody;PDCD6IP antibody;Programmed cell death 6 interacting protein antibody;Programmed cell death 6-interacting protein antibody

POST-TRANSLATIONAL MODIFICATION

May be phosphorylated on tyrosine residues by activated PDGFRB.

SUBCELLULAR LOCATION

Cell junction, Cytoplasm, Cytoskeleton, Secreted, Tight junction.

FUNCTION

ALG-2-interacting protein (Alix), also designated programmed cell death 6-interacting protein (PDCD6-interacting protein), is a cytoplasmic protein. Alix interacts with apoptosis-associated proteins (ALG-2 and PDCD6) and with the endocytosis-regulator CIN85. Additionally, Alix interacts with the endosomal sorting complexes required for transport (ESCRT) proteins (Tsg101 and CHMP4) and can associate with HIV-1. The endophilins (SH3P4, SH3P8 and SH3P13), enzymes that change curvature of the membrane that are required for early and late steps of coated vesicle formation, also bind to Alix. Alix is involved in the concentration and sorting of cargo proteins of the multivesicular body for incorporation into vesicles.