Aldehyde Oxidase Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH0-17] (HA750589)

UNIPROT #

Q06278

PROTEIN NAME

Aldehyde Oxidase

SYNONYMS

Aldehyde oxidase 1 antibody;AO antibody;AOH1 antibody;AOX 1 antibody;azaheterocycle hydroxylase antibody;EC 1.2.3.1 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aldehyde oxidase 1 is an enzyme that in humans is encoded by the AOX1 gene. Aldehyde oxidase produces hydrogen peroxide and, under certain conditions, can catalyze the formation of superoxide. Aldehyde oxidase is a candidate gene for amyotrophic lateral sclerosis. Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with NADH or aldehyde as electron donor. May play a role in adipogenesis.