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Agrin Recombinant Rabbit Monoclonal Antibody [PSH19-50] (HA724076)

Price: Regular price $385.00

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Catalog# HA724076

Rabbit Monoclonal to Agrin

Tested for

  • WB

  • IF-Cell

  • FC

Reacts with

  • Human

  • Rat

Recombinant production enables lot-to-lot consistency and is animal-cruelty-free

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Specifications

Product Type

Recombinant Rabbit monoclonal primary

Product Name

Agrin Recombinant Rabbit Monoclonal Antibody [PSH19-50] (HA724076)

Host

Rabbit

Positive Control

HepG2 cell lysate, HT-29 cell lysate, U-2 OS cell lysate, NRK cell lysate, C6 cell lysate, HT-29.

Conjugation

Unconjugated

Clonality

Monoclonal

Clone Number

PSH19-50

APPLICATION DILUTION

  • WB

  • 1:5,000

  • IF-Cell

  • 1:100

  • FC

  • 1:1,000

PROPERTIES

Form

Liquid

Storage Condition

Shipped at 4C. Store at +4C short term (1-2 weeks). It is recommended to aliquot into single-use upon delivery. Store at -20C long term.

Storage Buffer

1*PBS (pH7.4), 0.1% BSA, 40% Glycerol, 0.2% Proclean 950.

Concentration

1ug/ul

Purification

Protein A affinity purified.

Molecular Weight

Predicted band size: 217 kDa

Isotype

IgG

TARGET

UNIPROT #

O00468

PROTEIN NAME

Agrin

SYNONYMS

AGRIN antibody;Agrin C-terminal 22 kDa fragment antibody;Agrin proteoglycan antibody;AGRIN_HUMAN antibody;Agrn antibody;C22 antibody;C90 antibody;FLJ45064 antibody;OTTHUMP00000044043 antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Agrin is a large proteoglycan whose best-characterised role is in the development of the neuromuscular junction during embryogenesis. Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this protein is encoded by the AGRN gene. This protein has nine domains homologous to protease inhibitors. It may also have functions in other tissues and during other stages of development. It is a major proteoglycan component in the glomerular basement membrane and may play a role in the renal filtration and cell-matrix interactions. Agrin functions by activating the MuSK protein (for Muscle-Specific Kinase), which is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular junction. Agrin is required to activate MuSK. Agrin is also required for neuromuscular junction formation.

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