ACADM Recombinant Rabbit Monoclonal Antibody [JE48-09] (ET7109-74)

UNIPROT #

P11310

PROTEIN NAME

ACADM

SYNONYMS

ACAD 1 antibody;ACAD1 antibody;Acadm antibody;ACADM_HUMAN antibody;Acyl coenzyme A dehydrogenase antibody;Acyl coenzyme A dehydrogenase C 4 to C 12 straight chain antibody;FLJ18227 antibody;FLJ93013 antibody;FLJ99884 antibody;MCAD antibody;MCADH antibody;Medium chain acyl CoA dehydrogenase antibody;Medium chain fatty acyl CoA dehydrogenase antibody;Medium chain specific acyl CoA dehydrogenase antibody;Medium chain specific acyl CoA dehydrogenase mitochondrial antibody;Medium-chain specific acyl-CoA dehydrogenase antibody;mitochondrial antibody

SEQUENCE SIMILARITIES

Belongs to the acyl-CoA dehydrogenase family.

POST-TRANSLATIONAL MODIFICATION

Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity (By similarity). These sites are deacetylated by SIRT3.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as milk and certain oils, and they are also stored in the body's fat tissue. Medium-chain fatty acids are also produced when larger fatty acids are degraded. The acyl-coenzyme A dehydrogenase for medium-chain fatty acids (ACADM) enzyme is essential for converting these particular fatty acids to energy, especially during periods without food (fasting). The ACADM enzyme functions in mitochondria, the energy-producing centers within cells. It is found in the mitochondria of several types of tissues, particularly the liver. The LCAD enzyme catalyzes most of fatty acid beta-oxidation by forming a C2-C3 trans-double bond in the fatty acid. MCAD works on long-chain fatty acids, typically between C4 and C12-acylCoA. Fatty acid oxidation has proven to spare glucose in fasting conditions, and is also required for amino acid metabolism, which is essential for the maintenance of adequate glucose production. Furthermore, MCAD participates in fatty acid metabolism and PPAR signaling pathway.