Alpha-Synuclein Recombinant Rabbit Monoclonal Antibody [PSH08-83] (HA723035)

UNIPROT #

P37840

PROTEIN NAME

Alpha-Synuclein

SYNONYMS

Alpha synuclein antibody;Alpha-synuclein antibody;Alpha-synuclein, isoform NACP140 antibody;alphaSYN antibody;MGC105443 antibody;MGC110988 antibody;MGC127560 antibody;MGC64356 antibody;NACP antibody;Non A beta component of AD amyloid antibody;Non A4 component of amyloid antibody;Non A4 component of amyloid precursor antibody;Non-A beta component of AD amyloid antibody;Non-A-beta component of alzheimers disease amyloid , precursor of antibody;Non-A4 component of amyloid precursor antibody;Non-A4 component of amyloid, precursor of antibody;OTTHUMP00000218549 antibody;OTTHUMP00000218551 antibody;OTTHUMP00000218552 antibody;OTTHUMP00000218553 antibody;OTTHUMP00000218554 antibody;PARK 1 antibody;PARK 4 antibody;PARK1 antibody;PARK4 antibody;Parkinson disease (autosomal dominant, Lewy body) 4 antibody;Parkinson disease familial 1 antibody;SNCA antibody;Snca synuclein antibody;Snca synuclein, alpha (non A4 component of amyloid precursor) antibody;SYN antibody;Synuclein alpha antibody;Synuclein alpha 140 antibody;Synuclein, alpha (non A4 component of amyloid precursor) antibody;SYUA_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Membrane, Nucleus, Synapse, Secreted, Cell projection, axon.

FUNCTION

Alpha-synuclein (aSyn) is a protein that, in humans, is encoded by the SNCA gene. Alpha-synuclein is a neuronal protein that regulates synaptic vesicle trafficking and subsequent neurotransmitter release. It is abundant in the brain, while smaller amounts are found in the heart, muscle and other tissues. In the brain, alpha-synuclein is found mainly in the axon terminals of presynaptic neurons. Within these terminals, alpha-synuclein interacts with phospholipids and proteins. Presynaptic terminals release chemical messengers, called neurotransmitters, from compartments known as synaptic vesicles. The release of neurotransmitters relays signals between neurons and is critical for normal brain function. In Parkinson's disease and other synucleinopathies, insoluble forms of alpha-synuclein accumulate as inclusions in Lewy bodies. Familial Parkinson's disease is associated with mutations in the -synuclein (SNCA) gene. In the process of seeded nucleation, alpha-synuclein acquires a cross-sheet structure similar to other amyloids.